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- W2391954772 abstract "Objective The aim of this study was to observe the pathological changes in lungs perfused with the low potassium dex- tran glucose(LPD)solution at 4℃ in preservation of the non-heart-beating donor(NHBD)lung in lung transplantation LTx,and to as- sess the protective effects of LPDS in LTx of NHBD.Methods The warm ischemic time was 7 to 10 minutes respectively for cadaveric LTx,the lungs were perfused either antegradely or retrogradely with LPD.Lungs biopsies were performed before cold ischaemic storage at 4℃ for 6 h,12 h,18 h,24 h respectively and 1 h after reperfusion.Histopathological changes of the lungs were observed during isch- emia and reperfusion.Results The histolopathologic examination on all groups revealed almost normal lung structure without alveolar wall thickening or edema,the small bronchi structure and epithelial cell was almost normal without intra-alveolar hemorrhage.Only slight to mild infiltration of the inflammatory cells and macrophagus was seen in the alveolar wall or alveolar space or alveoli of lung were col- lapsed during cold ischaemic storage at 4℃ for 12 h,18 h,24 h.After reperfusion alveolar capillaries were engorge,mild infiltration of the inflammatory cells and minimal interstitial edematous was seen in the perivascular.Conclusion LPD solution may be safely applied in clinical cadaveric LTx with extended donor lungs ischemic times because of its excellentpreservation ability." @default.
- W2391954772 created "2016-06-24" @default.
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- W2391954772 date "2007-01-01" @default.
- W2391954772 modified "2023-09-28" @default.
- W2391954772 title "Histopathological investigation of protective effects of low potassium dextran glucose solution on non-heart-beating donor lungs" @default.
- W2391954772 hasPublicationYear "2007" @default.
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