Matches in SemOpenAlex for { <https://semopenalex.org/work/W2391962420> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2391962420 abstract "Objective To evaluate the effects of recombinant adenovirus-p53(Gendicine) combined with docetaxel on the growth inhibition of human lungadenocarcinoma cell lines.Methods Human lung adenocarcinomacell lines GLC-82(including mutant p53) and A549(including wild-type p53) were treated with Ad-p53,docetaxel or Ad-p53+docetaxel respectively.p53 expression was detected by Western blot.The cell growth inhibition and cell cycle apoptosis were assessed with MTT and flow cytometry.Results High-level p53 expression was detected in Ad-p53 infected GLC-82 and A549 cells by Western blot.There was a dose-dependent and time-dependent inhibition of cell proliferation by Ad-p53.After combining treatment with Ad-p53(100MOI) and docetaxel (5 mg/L) for 72 hours,the growth inhibition rate of A549 cells was(51.96±0.76)%,which was significantly higher than that in Ad-p53 group(23.44±0.54)% and docetaxel group(40.53±1.37)%;and the growth inhibition rate of GLC-82 cells was(62.42±1.43)%,which was significantly higher than that in Ad-p53 group(41.51±0.59)% and docetaxel group(48.39±0.88)%.Combined administration of Ad-p53 and docetaxel remarkably arrested A549 and GLC-82 cells in G_0～G_1,and cells in Sphase significantly decreased.Meanwhile the apoptotic rate of A549 cells was(23.35±0.64)% in Ad-p53+docetaxel group,which was significantly higher than that in Ad-p53 group(15.35±1.31)% and docetaxel group(0.93±0.35)%.The apoptotic rate of GLC-82 cells was(47.73±1.17)% in Ad-p53+docetaxel group,which was significantly higher than that in Ad-p53 group(20.88±0.71)% and docetaxel group(1.16±0.52)%.Conclusion Ad-p53(Gendicine) combined with docetaxel shows significantly synergistic inhibition effects on the growth of human lung adenocarcinoma cell lines." @default.
- W2391962420 created "2016-06-24" @default.
- W2391962420 creator A5090906124 @default.
- W2391962420 date "2006-01-01" @default.
- W2391962420 modified "2023-09-25" @default.
- W2391962420 title "EFFECT OF RECOMBINANT ADENOVIRUS-p53 COMBINED WITH DOCETAXEL ON THE GROWTH INHIBITION OF HUMAN LUNG ADENOCARCINOMA CELL LINES" @default.
- W2391962420 hasPublicationYear "2006" @default.
- W2391962420 type Work @default.
- W2391962420 sameAs 2391962420 @default.
- W2391962420 citedByCount "0" @default.
- W2391962420 crossrefType "journal-article" @default.
- W2391962420 hasAuthorship W2391962420A5090906124 @default.
- W2391962420 hasConcept C104317684 @default.
- W2391962420 hasConcept C121608353 @default.
- W2391962420 hasConcept C126322002 @default.
- W2391962420 hasConcept C143998085 @default.
- W2391962420 hasConcept C153911025 @default.
- W2391962420 hasConcept C16685009 @default.
- W2391962420 hasConcept C190283241 @default.
- W2391962420 hasConcept C203014093 @default.
- W2391962420 hasConcept C2776256026 @default.
- W2391962420 hasConcept C2776415932 @default.
- W2391962420 hasConcept C2776694085 @default.
- W2391962420 hasConcept C2779707156 @default.
- W2391962420 hasConcept C2780783641 @default.
- W2391962420 hasConcept C2781190966 @default.
- W2391962420 hasConcept C29537977 @default.
- W2391962420 hasConcept C502942594 @default.
- W2391962420 hasConcept C54355233 @default.
- W2391962420 hasConcept C553184892 @default.
- W2391962420 hasConcept C55493867 @default.
- W2391962420 hasConcept C62112901 @default.
- W2391962420 hasConcept C71924100 @default.
- W2391962420 hasConcept C81729549 @default.
- W2391962420 hasConcept C81885089 @default.
- W2391962420 hasConcept C86803240 @default.
- W2391962420 hasConceptScore W2391962420C104317684 @default.
- W2391962420 hasConceptScore W2391962420C121608353 @default.
- W2391962420 hasConceptScore W2391962420C126322002 @default.
- W2391962420 hasConceptScore W2391962420C143998085 @default.
- W2391962420 hasConceptScore W2391962420C153911025 @default.
- W2391962420 hasConceptScore W2391962420C16685009 @default.
- W2391962420 hasConceptScore W2391962420C190283241 @default.
- W2391962420 hasConceptScore W2391962420C203014093 @default.
- W2391962420 hasConceptScore W2391962420C2776256026 @default.
- W2391962420 hasConceptScore W2391962420C2776415932 @default.
- W2391962420 hasConceptScore W2391962420C2776694085 @default.
- W2391962420 hasConceptScore W2391962420C2779707156 @default.
- W2391962420 hasConceptScore W2391962420C2780783641 @default.
- W2391962420 hasConceptScore W2391962420C2781190966 @default.
- W2391962420 hasConceptScore W2391962420C29537977 @default.
- W2391962420 hasConceptScore W2391962420C502942594 @default.
- W2391962420 hasConceptScore W2391962420C54355233 @default.
- W2391962420 hasConceptScore W2391962420C553184892 @default.
- W2391962420 hasConceptScore W2391962420C55493867 @default.
- W2391962420 hasConceptScore W2391962420C62112901 @default.
- W2391962420 hasConceptScore W2391962420C71924100 @default.
- W2391962420 hasConceptScore W2391962420C81729549 @default.
- W2391962420 hasConceptScore W2391962420C81885089 @default.
- W2391962420 hasConceptScore W2391962420C86803240 @default.
- W2391962420 hasLocation W23919624201 @default.
- W2391962420 hasOpenAccess W2391962420 @default.
- W2391962420 hasPrimaryLocation W23919624201 @default.
- W2391962420 hasRelatedWork W2075521812 @default.
- W2391962420 hasRelatedWork W2183195026 @default.
- W2391962420 hasRelatedWork W2222700962 @default.
- W2391962420 hasRelatedWork W2348177775 @default.
- W2391962420 hasRelatedWork W2355845587 @default.
- W2391962420 hasRelatedWork W2356705010 @default.
- W2391962420 hasRelatedWork W2360671327 @default.
- W2391962420 hasRelatedWork W2368194476 @default.
- W2391962420 hasRelatedWork W2368276547 @default.
- W2391962420 hasRelatedWork W2379860949 @default.
- W2391962420 hasRelatedWork W2380638897 @default.
- W2391962420 hasRelatedWork W2380766536 @default.
- W2391962420 hasRelatedWork W2384138892 @default.
- W2391962420 hasRelatedWork W2384408296 @default.
- W2391962420 hasRelatedWork W2385027747 @default.
- W2391962420 hasRelatedWork W2386981752 @default.
- W2391962420 hasRelatedWork W2389461974 @default.
- W2391962420 hasRelatedWork W2391039679 @default.
- W2391962420 hasRelatedWork W3031079671 @default.
- W2391962420 hasRelatedWork W3149800471 @default.
- W2391962420 isParatext "false" @default.
- W2391962420 isRetracted "false" @default.
- W2391962420 magId "2391962420" @default.
- W2391962420 workType "article" @default.