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- W2391965562 abstract "ObjectiveTo evaluate the role of expired nitric oxide(Fe NO)level in chronic cough children to predictbronchial hyperresponsiveness by analyzing the correlation between fraction of expired nitric oxide and bronchial provo-cation test.MethodsWe conducted a study on 276 chronic cough children to measure their Fe NO concentration,andwe performed spirometry and methacholine provocation tests.ResultsAccording to the results of bronchial provocationtests,there were 122 cases positive(positive group)and 154 negative cases(negative group). The positive group had asignificantly higher Fe NO than negative group(20.0 × 10-9vs. 16.0 × 10-9,P=0.000). By constructing ROC curve,wefound that Fe NO cut-off value of 31. 5 ppb was able to identify bronchial hyperresponsiveness with high specificity(97.4%)and positive predictive value(89.5%)but low sensitivity(28.7%)and negative predictive value(63.0%).There was no relationship between the methacholine provocative dose causing a 20% fall in FEV1(PD20- FEV1)andthe level of Fe NO.ConclusionFe NO measurement has some predictable effects for bronchial hyperreactivity in chil-dren with chronic cough. The level of Fe NO31.5×10-9has high predictive value in chronic cough children with bronchi-al hyperreactivity. However,Fe NO31.5×10-9does not rule out bronchial hyperreactivity and should call for a bronchi-al provocation test." @default.
- W2391965562 created "2016-06-24" @default.
- W2391965562 creator A5062542913 @default.
- W2391965562 date "2015-01-01" @default.
- W2391965562 modified "2023-09-23" @default.
- W2391965562 title "Clinical value of expired nitric oxide level in predicting bronchial hyperreactivity in children with chronic cough" @default.
- W2391965562 hasPublicationYear "2015" @default.
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