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- W2391966700 abstract "Objective Exposure to hypoxia induces hypoxic pulmonary hypertension(HPH),the effects of taurine(Tau) and L-arginine(Arg), and their combination(TA) on prevention against HPH were investigated.Methods Adult male Wistar rats were divided into two groups: sea level control group(C) and hypoxia group,and the hypoxia group was divided into three subgroups further,namely hypoxia control(H),Tau,Arg and TA group.The therapy groups were given corresponding drugs every day orally.After exposed for 2 weeks in a hypobaric chamber at simulated high altitude of 5 000 meters,the effects of the above drugs were evaluated.Results The rats of H group developed remarkable HPH and right ventricle hypertrophy(RVH),with an elevated mean pulmonary artery pressure(mPAP) of about 25 mmHg above and the right ventricular hypertrophy index(RVHI) of 1.56 folds higher(P0.01). The activity of lactic dehydrogenase(LDH) and level of malondialdehyde(MDA) in the plasma of H group were 10.1 and 1.64 folds higher than those of respective control groups(P0.01),while the NO production in the lung tissue of H group was 68% lower than that of C group(P0.01).The development of HPH and RVH was ameliorated in the groups with the above drugs administered respectively,with about 5 mmHg of mPAP below(P0.05),and RVHI about 20% lower than those of H group(P0.01).The activity of LDH in each therapy group showed markedly decreases(P0.01,TA vs Arg,P0.01),and the levels of MDA also showed significant decreases(P0.01).NO productions in the lung tissues resumed of Arg and TA groups(P0.01).Conclusion The results suggest that taurine,L-arginine and their combinaion exert cytoprotective effects on hypoxic injury,inhibit lipidperoxidation,mitigate hypoxic pulmonary hypertension and reduce right ventricle hypertrophy." @default.
- W2391966700 created "2016-06-24" @default.
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- W2391966700 date "2006-01-01" @default.
- W2391966700 modified "2023-09-25" @default.
- W2391966700 title "Protection against hypoxic injury and amelioration of hypobaric hypoxic pulmonary hypertension by treating with L-arginine combined taurine in rats" @default.
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