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- W2391993451 abstract "Objective To study the HPRT gene locus mutations induced by cigarette smoke and its major component 4,(methylnitrosamino),1,(3,pyrodyl),1,butanone (NNK). Methods HPV,18 immortalized human bronchial epithelial cells (BEP2D) were used as the target cells. Cigarette smoke condense (CSC) was collected from a famous brand cigarette (mixed cigarette, the amount of tar were marked by 8 mg per cigarette), and the content of NNK in the CSC was detected by GC,TEA. A rapid and sensitive multinuclear cell assay was used to detect the frequency of the HPRT gene mutation in BEP2D cells induced by NNK and CSC. Results Content of CSC in the cigarettes was (7.93±0.89) mg per cigarette, content of NNK in the CSC was (0.046±0.008)μg per cigarette. The frequency of HPRT gene mutation in BEP2D cells (y1 and y2) presented dependent on the concentrations of NNK and CSC(x1 and x2), and the dose,effect relationship were: y1=0.016x1+1.012 and y2=0.0061x2+1.042 respectively. However, result computed base on above formula indicated that, in a cigarette, the fraction of NNK,induced HPRT gene mutation was only 0.002% less than that of CSC induced. Conclusion Both CSC and NNK could induce HPRT gene locus mutation but the fraction of NNK in a cigarette was minor." @default.
- W2391993451 created "2016-06-24" @default.
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- W2391993451 date "2004-01-01" @default.
- W2391993451 modified "2023-10-06" @default.
- W2391993451 title "HPRT Gene Locus Mutation of HPV-18 Immortalized Human Bronchial Epithelial Cells Induced by Cigarette Smoke Condense and Its Major Harmful Component" @default.
- W2391993451 hasPublicationYear "2004" @default.
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