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- W2392002904 abstract "Objective: To investigate the value of combined blockade Ras and mTOR signaling in the therapy of HCC. Methods: Specific Ras and/or mTOR inhibitors were used to inhibit Ras and mTOR relatively. Cell proliferation was assessed by using the MTT assay. Early apoptosis was detected by Annexin-V-FITC/propidium iodide double staining assay. The effects of the two drugs on HCC were also assessed in xenograft models. Results: Ras inhibitor FTS and mTOR inhibitor all inhibited HepG2 and Huh-7 cell growth, induced cell apoptosis. Conclusion: Con-target Ras and mTOR could markedly inhibited HCC cell growth in vitro and in vivo." @default.
- W2392002904 created "2016-06-24" @default.
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- W2392002904 date "2014-01-01" @default.
- W2392002904 modified "2023-09-22" @default.
- W2392002904 title "Combined blocked of Ras and mTOR signaling inhibit HCC cell growth" @default.
- W2392002904 hasPublicationYear "2014" @default.
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