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- W2392005095 abstract "Objective To study the risk factors of early onset(below 45 year old) coronary heart disease(CHD) .Methods 189 patients under 45-year-old with coronary arteriography in hospital from September, 2003 to December, 2005 were included.The patients were divided into two groups:126 patients with coronary artery lumens' stenosis over 50% were in CHD group, and the other 63 ones were in control group.All patients had medical history recorded and blood biochemical indicator determined.Genomic DNA was isolated from the patients' white blood cells in phenol / chloroform method.Fibrinogen bHae111 gene polymorphism was detected by polymerase chain reaction(PCR) and incision enzyme.Plasma fibrinogen was de-termined in thrombin method, and serum total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDLC), high density lipoprotein cholesterol(HDL-C) were determined in standard enzymic method.Patients with hypertension and / or diabetes had been finally diagnosed.The smoker was defined as smoking over one cigarette / day for more than one year.SPSS11.0 software was used for statistical analyses.t test and χ2 test were used for risk factor analyses.P﹤0.05 was considered significant deviation statistically.Results There was no significant difference between the two groups in mean age, distribution of gender, TC, TG, LDLC and levels of plasma fibrinogen.However, the factors such as smoking, hypertension, diabetes, serum HDL-C concentration and fibrinogen bHae111 gene polymorphism were remarkably different, as listed in the table.Conclusion Smoking, hypertension, diabetes, lower concentration of serum HDL-C and fibrinogen bHae111 gene polymorphism are the risk factors of early onset CHD." @default.
- W2392005095 created "2016-06-24" @default.
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- W2392005095 date "2008-01-01" @default.
- W2392005095 modified "2023-09-23" @default.
- W2392005095 title "ANALYSE OF RISK FACTORS IN PATIENTS WITH CORONARY HEART DISEASE BELOW THE AGE OF 45 YEARS" @default.
- W2392005095 hasPublicationYear "2008" @default.
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