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- W2392019968 abstract "Objective To investigate the effects of glutamine(Gln) and epidermal growth factor(EGF) on small intestinal repair in neonatal rats with necrotizing enterocolitis(NEC).Methods Forty neonatal rats of NEC model were divided into 5 groups:group A(control group),group B(NEC model),group C(NEC+Gln),group D(NEC+EGF+Gln).After NEC model of neonatal rats,all the neonatal rats were returned to their mothers.In the 4~(th) day,all the subjects were put to the death.Intestinal tissue located at the boundary of ileum and cecum was obtained to observe histological changes.Morphological changes were measured under a light microscope,and expression of proliferating cell nuclear antigen(PCNA) as an index of cell proliferation was observed using immunohistochemical staining and image analysis,expression of apoptosis was observed by TUNEL staining and image analysis.Results In group B,the histological lesions ranged was different,and was graded 3 score.In group C,D,the histological lesions ranged was graded 1 score.The number of(PCNA) in group B was lower than that in group A(P0.01);The number of(PCNA) in group C,D was higher than that in group B(P0.01);The number of PCNA in group D was higher than that in group C(P0.05).The number of apoptosis in group B was higher than that in group A(P0.01);The number of apoptosis in group C,D were lower than those in group B(P0.01);The numbers of apoptosis in group D was lower than that in group C(P0.05).Conclusions NEC can damage neonate rats intestinal mucosa,step down proliferation of intestinal mucosa,and to increase number of apoptosis in intestinal mucosa.Gln and EGF can improve the proliferation of crypt cell,reduce apoptosis of intestinal mucosa,and promote repair of intestinal mucosa after NEC." @default.
- W2392019968 created "2016-06-24" @default.
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- W2392019968 date "2006-01-01" @default.
- W2392019968 modified "2023-09-26" @default.
- W2392019968 title "Effect of Glutamine and Epidermal Growth Factor on Neonatal Rats with Necrotizing Enterocolitis" @default.
- W2392019968 hasPublicationYear "2006" @default.
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