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- W2392019997 abstract "The potassium inotophoresis induced tail flick was used to measure the pain threshold(PT) of rats. The changes of PT were investigated by microinjecting L arginine( L Arg) and methylene blue(MB) et al into cerebral ventricular of rats. The significant hyperalgesic effects were observed by injecting L Arg and sodium nitroprusside (SNP) into cerebral ventricular of rats. The PT of rats was increased significantly by microinjecting MB and N G nitro L arginine methyl ester( L NAME) into ventricular of brain. When the MB plus L Arg mixed liquid (MB+ L Arg group) was injected into cerebral ventricular of rats,the PT of rats was decreased compared with that of MB group,but it was increased more than that of L Arg group. These results suggested that an increase of NO in brain produce hyperalgesia,and a decrease of NO level produce analgesia. The effects of nitric oxide on modulation of pain in central nervous system of rats may be partially mediated by NO cyclic GMP pathway." @default.
- W2392019997 created "2016-06-24" @default.
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- W2392019997 date "2000-01-01" @default.
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- W2392019997 title "The effect of nitric oxide on modulation of pain in central nervous system of rats" @default.
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