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- W2392022225 abstract "Objective To evaluate the modulated role of Adrenomedullin-2(ADM2) in vascular smooth muscle cell proliferation induced by angiotensin Ⅱ(Ang Ⅱ).Methods Aortic vascular smooth muscle cells(VSMCs) from cultured rats were used for the present studies.In the absence of serum cells were cultured with placebo as control(n=6),or with ADM2(10-9-10-6 mol/L,n=24),or Ang Ⅱ(10-7 mol/L,n=6),or Ang Ⅱ(10-7mol/L)+ ADM2(10-9-10-6 mol/L)(n=24),or Ang Ⅱ(10-7 mol/L)+ADM2(10-9 mol/L)+ ADM22-52(10-7 mol/L) or CGRP8-37(10-7 mol/L)(n=12).VSMCs proliferation were determined by measuring 3H-Thymidine incorporation,cell number,uptake of 3-(4,5-dimethylthiazol-2-yl)-diphenyl-tetrazolium bromide(MTT).Results ADM2 doses dependently stimulated VSMCs proliferation and in the range of(10-9-10-6 mol/L).On contrary,ADM2 inhibited the increases of 3H-Thymidine incorporation into VSMCs,and the elevated DNA composition induced by Ang Ⅱ by 28%,32%,44% and 52%,all P0.01;MTT optical density showed the proliferation rate by Ang Ⅱ was attenuated by 9%,14%,16% and 20%(all P0.01).Co-cultured with CGRP8-37 or ADM22-52 offset the inhibition effect by ADM2(P0.01).Conclusion The present study showed that ADM2 significantly inhibit Ang Ⅱ induced VSMCs proliferation.The clinical significance of the inhibition effect by ADM need further investigated." @default.
- W2392022225 created "2016-06-24" @default.
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- W2392022225 date "2009-01-01" @default.
- W2392022225 modified "2023-09-24" @default.
- W2392022225 title "The Modulated Role of Adrenomedullin-2 in Vascular Smooth Muscle Cell Proliferation Induced by Angiotensin II" @default.
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