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- W2392036204 abstract "Objectives FSM 2117 and FS 5416 are two bivalent hybrid strains of S. flexneri and S. sonnei, constructed by our laboratory. The differences of them are that the FS 54116 expresses four invasive plasimid antigens and has a good contact heamolysis activity(CHA +), but the FSM 2117 does not. To observe the mechanism of immune protection of Shigella vaccine, the changes of CD4 + and CD8 + T subsets in GALT in mice are detected. Methods BALB/c mice were divided into two groups, 25 mice per group. The two groups were immunized respectively with the two vaccines(8×10 8CFU/per mouse) four times with an interval of seven days by pouring the vaccine down the throat. The Peyer's patch(PP), mesenteric lymph nodes(MLN), intraepithelial(IE), lamina propria(LPL) and spleen(SP) lymphocytes were isolated of the same time on the first, fourth, seventh, tenth, thirteenth day at random after immunization. A PBS immunized group was detected as control. An indirect immuno fluorescence assay was done. And 200 cells were counted under fluorescence microscope. Results The data were analysed with SAS software (ANOVA). And it could be observed that the CD4 + subset of the two immunized groups showed a significant rise in PP and MLN of induced sites and LP effective site, and the CD8 + subset rose in IE of effective sites. The responses of both the two groups were significantly different from that of controls(FSM 2117, P ≤0 01,FS 5416 P 0 01). Conclusions Immunization with the two Shigella vaccines can result in immune responses in GALT in mice, and both two vaccines have better immunogenicity." @default.
- W2392036204 created "2016-06-24" @default.
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- W2392036204 date "1999-01-01" @default.
- W2392036204 modified "2023-09-22" @default.
- W2392036204 title "Changes of CD4+ and CD8 + T subsets in GALT of mice after immunization with two different bivalent Shigella vaccines" @default.
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