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- W2392040864 abstract "Objective To investigate the effect and mechanisms of glucosamine sulfate(GS) on chronic myloid leukemia K562 cells.Methods Exposured K562 cells in an exponential growth to 0.5,1.0,5.0 mmol/L GS and then test the inhibitive effect by cell counting.Morphologic evidence for apoptosis of GS inducing on K562 cells was determined by transmission electron microscope.The detection of DNA Ladder was tested by agarose gel electrophoresis.Sub-G1,cell cycle and Annexin V was detected by flow cytometry.Western blot was performed to detect the expression of activated caspase-3 and bcl-2.Results Treatment with 0.5,1.0, 5.0 mmol/L GS resulted in a concentration-dependent reduction in K562 cells growth(P0.01).The characteristic morphological changes of apoptosis were observed in K562 cells treated by GS by Wright-Gimsa and AO/EB staining.The proportion of G 1 cells was increased and the sub-G1 phase was 5.9%.K562 cells treated by GS were observed to have characteristic morphological changes of apoptosis.Treatment of K562 cells with 5 mM GS for 2～3 days resulted in the induction of apoptosis as assayed qualitatively by agarose gel electrophoresis and quantitatively by Annexin V.K562 cells treated by GS for 2-3 days expressed activated Caspase-3.However,the expression of Bcl-2 was downregulated.Conclusion GS could induce apoptosis of chronic myelogenous leukemia K562 cells with activation of Caspase-3 and downregulation of Bcl-2." @default.
- W2392040864 created "2016-06-24" @default.
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- W2392040864 date "2005-01-01" @default.
- W2392040864 modified "2023-09-27" @default.
- W2392040864 title "Study on the Apoptosis of K562 Cells Induced by Glucosamine Sulfate" @default.
- W2392040864 hasPublicationYear "2005" @default.
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