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- W2392043909 abstract "[Objective]To set up an exposure model of and explore the mechanism of Environmental Tobacco Smoke and Major components leading to Addiction and Toxicity in Mice.[Methods]1. Localizing the region and recording the changes of potentials. 2. Testing the expression of Neurotransmitters.[Results]1.The results of Olfactory Event-related Potential(OERP):(1)The results of OERP on Olfactory bulb(OB):Waveforms significantly changed when the mice were forced to inhale ETS.(2)The results of OERP on Nucleus Accumbens septi(NA):Waveforms significantly changed when the mice were forced to inhale nicotine.(3)The results of OERP on Substantia Nigra(SN):Waveforms significantly changed when the mice were forced to inhale NiC or ETS. 2.The immunohistochemistry results:(1)the expression of GABA on the mice cerebral cortex(CC)and the hippocampus(Hip)could be observed much higher on the ETS-exposed group than the control group(P﹤0.05).(2)the expression of nAChR on CC could be found much higer on the ETS-exposed group than the control group(P﹤0.05).(3)the expression of NMDAR(Glu receptors)on the CC and striate cortex could be observed much higher on the ETS-exposed group,NIC-inhaling group and the control group(P﹤0.05).[Conclusion]Long-term ETS-exposed and NiC-exposed environment could induce specific OERP and the changes on the expression of neurotransmitter and receptors." @default.
- W2392043909 created "2016-06-24" @default.
- W2392043909 creator A5074550797 @default.
- W2392043909 date "2011-01-01" @default.
- W2392043909 modified "2023-09-25" @default.
- W2392043909 title "THE PRELIMINARY STUDY OF THE INFLUENCE ON BRAIN EVOKED POTENTIAL AND THE EXPRESSION OF NEUROTRANSMITTERS AFTER MICE SMOKE EXPOSURE" @default.
- W2392043909 hasPublicationYear "2011" @default.
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