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- W2392048654 abstract "Objective To study the effect of capsaicin on cell growth and the expression of Bcl-2/Bax protein in human colon cancer cell line SW-480. Methods The SW-480 cells were treated with capsaicin at various concentrations for 48h. Growth suppression was evaluated by MTT method. Transmission electron microscopy (TEM) and DNA agarose gel electrophoresis were used to ascertain apoptosis-related alterations in morphology and biochemistry. Flow cytometry (FCM) was used to investigate the apoptotic rate. Western blotting was used to detect the protein expression of Bcl-2/Bax genes.Results Obvious inhibitory effect of capsaicin on SW-480 cells was dose -dependent. Under transmission electron microscopy, cells treated with capsaicin exhibited characteristics of apoptosis including cell membrane shrinkage, cytoplasm blebbing, condensation and fragmentation of nuclear chromatin and the formation of apoptotic bodies. DNA ladder of human SW-480 cells could be demonstrated on DNA electrophoresis after 100μg/ml capsaicin treatment for 24h. This increase in apoptosis was accompanied with a decrease in Bcl-2 expression and an increase in Bax expression. Conclusion Capsaicin inhibits the proliferation of SW-480 cells. Apoptotic induction may be the main antineoplastic mechanism, which is mediated by altering apoptosis-related genes through down-regulation of Bcl-2 and up-regulation of Bax proteins." @default.
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- W2392048654 date "2007-01-01" @default.
- W2392048654 modified "2023-09-23" @default.
- W2392048654 title "Effect of capsaicin on cell growth and the protein expression of Bcl-2/Bax genes in human colon cancer cell line SW-480" @default.
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