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- W2392056560 abstract "Objective To investigate the method of establishing lymph node metastasis model for gastric cancer in nude mice.Methods Human poorly differentiated gastric cancer SGC-7901 ceils were cul- tured,inherited,amplified and collected in vitro,and were inoculated in nude mice subcu.taneously.After pas- saging six generations,the subcutaneous tumor was orthotopically implanted in nude mice.The mice were then sacrificed on the 9th week after implantation.Serum CEA density was detected using radio-immunity method. Orthotopically implanted tumors,remote organ metastases as well as lymph node metastasis were observed macrescopically and histologically.Results The successful rate of orthotopically transplantion of gastric can- cer was 100 %.The rate of perigastric lymph node metastases was 93.3 %.Local infiltration and remote metastasis were observed.The level of serum CEA in nude mice bearing tumor was significantly higher than that of normal nude mice(P0.01).Conclusion Animal model of gastric cancer lymph node-metastasis was successfully established using SGC-7901 cell line." @default.
- W2392056560 created "2016-06-24" @default.
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- W2392056560 date "2007-01-01" @default.
- W2392056560 modified "2023-09-23" @default.
- W2392056560 title "Establishment of lymphatic metastasis model for human gastric cancer in nude mice" @default.
- W2392056560 hasPublicationYear "2007" @default.
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