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- W2392060557 abstract "[Objectives] To investigate the urodynamic effects of electroacupuncture at CiLiao(BL 32) on overactive bladder(OAB) in rats induced by cyclophsphamide(CYP)and expressions of calcitonin-gene related peptide(CGRP)and SP in dorsal horn of spinal cord.[Methods] Twenty five Sprague-Dawley rats were randomly divided into: control group(n=5),chronic OAB group(n=10),chronic OAB+electroacupuncture group(n=10).OAB model was established by intraperitoneal injection(i.p.i) of cyclophsphamide,continuous cystometry was performed to detectinter-contraction interval,basal,threshold,micturition voiding pressure before and after electroacupuncture.The expressions of CGRP and SP in the dorsal horn of spinal cord were detected by immunohistochemical method.[Results] Compared with control group,inter-contraction interval was decreased(P0.05) and basal pressure was increased(P0.01) in both OAB and ele-ctroacupuncture group before acupuncture.While basal pressure was decreased and inter-contraction interval was increased significantly in acupuncture group compared with those in control group(P0.01).Comparison with control group,the mean optical density(OD) value of SP and CGRP positive products in the dorsal horn of sacral cord in OAB group was increased significantly(P0.05),while compared with OAB group,the mean OD value of SP and CGRP in acupuncture group was decreased(P0.05).[Conclusions] Electroacupuncture at CiLiao could inhibit the overactive bladder induced by cyclophsphamide in rats by decreasing the SP and CGRP expressions in the dorsal horn of spinal cord." @default.
- W2392060557 created "2016-06-24" @default.
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- W2392060557 date "2012-01-01" @default.
- W2392060557 modified "2023-09-26" @default.
- W2392060557 title "Urodynamic effects of electroacupuncture at Ciliao on overactive bladder in rats and CGRP,SP expressions of dorsal horn of spinal cord" @default.
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