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- W2392071676 abstract "Objective The end of the report further validation based on migraine patients( patients reported outcomes,PRO) evaluation questionnaire of clinical application. Method The multi-center,prospective,randomized,double-blind,positive drug parallel contrast research method was performed. By15 clinical research centers,from February 2012 to February 2014,357 patients in accordance with the inclusion criteria were collected. Data were input and managed by EPIDATA database. SPSS16. 0 was used for data analysis. The number of headache attack,days of headache,PRO scale scores,and four dimensions scores were observed at the following time points: before treatment,after treatment for 4,8 and 12 weeks,follow-up visit. Chi-square test and rank-sum test were used to analyze frequences; Measurement data were expressed as and analyzed using matching t test. Correlation analysis was used to observe the correlation. Result Both the number of headache attack and days of headache were improved after treatment for4,8 and 12 weeks compared with baseline and there were significant differences( P 0. 01). There was significant difference in PRO scale scores before and after treatment( P 0. 01); PRO scale four dimensions scores were significant different after treatment in comparison with before treatment( P 0. 01). At each time point,correlation coefficient between headache days,attack frequency and PRO scale scores waslarge than 0. 5,with moderate relevant; correlation coefficient between headache days,attack frequency and PRO scale four dimensions scores was larger than 0. 7,with strong relevant. Conclusion Migraine PRO scale could exactly reflect patients with significant changes in headache days,the number of attacks,and the PRO scale could imply treatment effect from multiple time points and multiple dimensions." @default.
- W2392071676 created "2016-06-24" @default.
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- W2392071676 date "2015-01-01" @default.
- W2392071676 modified "2023-09-27" @default.
- W2392071676 title "Clinical research of migraine pain remission based on patients-reported outcomes" @default.
- W2392071676 hasPublicationYear "2015" @default.
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