Matches in SemOpenAlex for { <https://semopenalex.org/work/W2392094252> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2392094252 abstract "Objective To investigate the effects of rare earth compound (lanthanum chloride, LaCl3) on the growth and apoptosis of K562 cells. Methods To investigate the effects of LaCl3 on the growth of K562 cells by MTT assay, the apoptosis detected by flow cytometry and TUNEL method, the cell cycle of K562 cells treated with LaCl3, and analyzed by flow cytometry, to evaluate the hematopoietic ability of normal bone marrow cells treated by LaCl3 by counting the granulocyte-macrophage colonies. Results MTT assay showed that treatment with 0.1, 0.5, 1.0, 1.5 and 2.0 mmol/L LaCl3 for 24 h, 48 h and 72 h could inhibit the growth of K562 cells. Apoptosis could be detected on treatment with 0.1, 0.5, 1.0, 1.5 and 2.0 mmol/L LaCl3 for 48 h in K562 cells by light microscopy morphology examination, and flow cytometry analysis. 1.0mmol/L for 24 h, 48 h, 72 h and 96 h treatment with 1mmol/L LaCl3 could significantly induce K562 apoptosis by flow cytometry and TUNEL method. Treatment of 1 mmol/L LaCl3 could arrest the transitions of K562 cells from G0/G1 to S phase. The granulocyte-macrophage colony formation (CFU-GM) of normal bone marrow cells was not significantly inhibited in treatment with 0.05 and 1.0 mmol/L LaCl3, but slightly increased in 0.1 and 0.5 mmol/L. Treatment with higher concentrations (1.5 to 2.0 mmol/L LaCl3), the colony formation was significantly inhibited. Conclusion Our data demonstrate that LaCl3 (0.1 to 1.0 mmol/L) may inhibit K562 cell growth and induce them to apoptosis." @default.
- W2392094252 created "2016-06-24" @default.
- W2392094252 creator A5017729534 @default.
- W2392094252 date "2006-01-01" @default.
- W2392094252 modified "2023-09-24" @default.
- W2392094252 title "Effects of lanthanum chloride on growth and apoptosis of K562 leukemia cell lines" @default.
- W2392094252 hasPublicationYear "2006" @default.
- W2392094252 type Work @default.
- W2392094252 sameAs 2392094252 @default.
- W2392094252 citedByCount "0" @default.
- W2392094252 crossrefType "journal-article" @default.
- W2392094252 hasAuthorship W2392094252A5017729534 @default.
- W2392094252 hasConcept C109159458 @default.
- W2392094252 hasConcept C153911025 @default.
- W2392094252 hasConcept C171122931 @default.
- W2392094252 hasConcept C179104552 @default.
- W2392094252 hasConcept C185592680 @default.
- W2392094252 hasConcept C190283241 @default.
- W2392094252 hasConcept C196795494 @default.
- W2392094252 hasConcept C203014093 @default.
- W2392094252 hasConcept C2778461978 @default.
- W2392094252 hasConcept C2780007613 @default.
- W2392094252 hasConcept C2780783641 @default.
- W2392094252 hasConcept C28328180 @default.
- W2392094252 hasConcept C29537977 @default.
- W2392094252 hasConcept C553184892 @default.
- W2392094252 hasConcept C55493867 @default.
- W2392094252 hasConcept C555894677 @default.
- W2392094252 hasConcept C62112901 @default.
- W2392094252 hasConcept C86803240 @default.
- W2392094252 hasConcept C95444343 @default.
- W2392094252 hasConceptScore W2392094252C109159458 @default.
- W2392094252 hasConceptScore W2392094252C153911025 @default.
- W2392094252 hasConceptScore W2392094252C171122931 @default.
- W2392094252 hasConceptScore W2392094252C179104552 @default.
- W2392094252 hasConceptScore W2392094252C185592680 @default.
- W2392094252 hasConceptScore W2392094252C190283241 @default.
- W2392094252 hasConceptScore W2392094252C196795494 @default.
- W2392094252 hasConceptScore W2392094252C203014093 @default.
- W2392094252 hasConceptScore W2392094252C2778461978 @default.
- W2392094252 hasConceptScore W2392094252C2780007613 @default.
- W2392094252 hasConceptScore W2392094252C2780783641 @default.
- W2392094252 hasConceptScore W2392094252C28328180 @default.
- W2392094252 hasConceptScore W2392094252C29537977 @default.
- W2392094252 hasConceptScore W2392094252C553184892 @default.
- W2392094252 hasConceptScore W2392094252C55493867 @default.
- W2392094252 hasConceptScore W2392094252C555894677 @default.
- W2392094252 hasConceptScore W2392094252C62112901 @default.
- W2392094252 hasConceptScore W2392094252C86803240 @default.
- W2392094252 hasConceptScore W2392094252C95444343 @default.
- W2392094252 hasLocation W23920942521 @default.
- W2392094252 hasOpenAccess W2392094252 @default.
- W2392094252 hasPrimaryLocation W23920942521 @default.
- W2392094252 hasRelatedWork W1200113000 @default.
- W2392094252 hasRelatedWork W2348210235 @default.
- W2392094252 hasRelatedWork W2350297975 @default.
- W2392094252 hasRelatedWork W2350350605 @default.
- W2392094252 hasRelatedWork W2350806407 @default.
- W2392094252 hasRelatedWork W2355064692 @default.
- W2392094252 hasRelatedWork W2355531672 @default.
- W2392094252 hasRelatedWork W2355963460 @default.
- W2392094252 hasRelatedWork W2358935734 @default.
- W2392094252 hasRelatedWork W2361680998 @default.
- W2392094252 hasRelatedWork W2367252699 @default.
- W2392094252 hasRelatedWork W2374704121 @default.
- W2392094252 hasRelatedWork W2377370409 @default.
- W2392094252 hasRelatedWork W2392017848 @default.
- W2392094252 hasRelatedWork W2394364159 @default.
- W2392094252 hasRelatedWork W2408222909 @default.
- W2392094252 hasRelatedWork W2462757443 @default.
- W2392094252 hasRelatedWork W3031346226 @default.
- W2392094252 hasRelatedWork W472778135 @default.
- W2392094252 hasRelatedWork W202890428 @default.
- W2392094252 isParatext "false" @default.
- W2392094252 isRetracted "false" @default.
- W2392094252 magId "2392094252" @default.
- W2392094252 workType "article" @default.