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- W2392106720 abstract "Objective To explore the expression of MMP-9,TIMP-1 and TGF-β1 in the asthmatic patients with irreversible airflow obstruction.Methods Forty-eight patients with asthma were chosen in the First Hospital of Shanxi Medical University from June to December 2008.According whether airflow obstruction was reversible or not being used β2-receptor agonists,they were divided into two groups:irreversible airflow obstruction group and reversible airflow obstruction one,and 24 patients each group,and control group included 10 persons.The sputum was induced with Saline,and the MMP-9,TIMP-1 and TGF-β1 level of the sputum and the blood were determined with ELISA.Results The levels of MMP-9,TIMP-1 and TGF-β1 in sputum and blood in asthma group were higher than those in the controlled group,and those in the irreversible airflow obstruction group were higher than the ones in the reversible airflow obstruction group.The MMP-9,TIMP-1 and TGF-β1 in the sputum had associated with those in blood.The MMP-9/TIMP-1 ratio in sputum and blood in asthma group were lower than those in the controlled group.The MMP-9/TIMP-1 ratio of the sputum in irreversible airflow obstruction group was lower than in the reversible airflow obstruction group,but there was no change in blood.Conclusions It was a safe and effective way that airway secretions were obtained through the induced sputum,MMP-9,TIMP-1 and TGF-β1 in the blood and induced sputum could be as biomarkers as irreversible airflow obstruction in asthmatic patients,MMP-9/TIMP-1 ratio in induced sputum was more sensitive to irreversible airflow obstruction than this in blood." @default.
- W2392106720 created "2016-06-24" @default.
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- W2392106720 date "2010-01-01" @default.
- W2392106720 modified "2023-09-26" @default.
- W2392106720 title "Relationship between the irreversible airflow obstruction of bronchial asthma and expression of MMP-9,TIMP-1 and TGF-β_1" @default.
- W2392106720 hasPublicationYear "2010" @default.
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