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- W2392107372 abstract "Objective To investigate the effect of exogenous wild type PTEN(phophatase and tensin homolog deleted on chromosome) gene transfer on the cell cycle progression and proliferation of ZR-75-1 human breast cancer cells,and to illustrate the mechanism that PTEN gene inhibits the proliferation of tumor cells.Methods pBP-wt-PTEN recombinant plasmids were transfected into ZR-75-1 cells by Lipofectamine.The stable express cells were selected by puromycin.The proliferation of tumor cells were examined by cell counted while the changes of cell cycle progression were by flow cytometry.Results Stable express cells were obtained by puromycin selection.The growth of ZR-75-1 was inhibited significantly by pBP-wt-PTEN stable transfering in vitro.The progression of cell cycle was arrested from G_1 to S phase,and one visible apoptotic peak in front of the peak of G_1 phase was also found by FCM.Conclusion The growth of ZR-75-1 breast cancer cells can be arrested at G_1 phase,and it can be significantly suppressed by exogenous PTEN gene transfering." @default.
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- W2392107372 date "2006-01-01" @default.
- W2392107372 modified "2023-09-27" @default.
- W2392107372 title "Effect of pBP-wt-PTEN transfected on the cell cycle progression and proliferation of ZR-75-1 human breast cancer cells." @default.
- W2392107372 hasPublicationYear "2006" @default.
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