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- W2392113829 abstract "OBJECTIVE To investgate the possiblility of percutaneous transport of niosomes inclusion of cinnamon volatile oil and the inluence of the concentrations and the type of penetration enhancer on the permeation rate.METHODSNiosomes were performed by Span40 and Chol.With the skin of SD male rat,the penetration experiments in vitro were performed on modified Franz diffusion cells.The amount of drug penetration concentrations of inclution compound was determined by HPLC.RESULTS Niosomes prepared by span40 and Chol According to 1∶1 ratio,the Average encapsulation efficiency can be achieved about 85%.The steady permeation rate of niosomes which Cinnamon oil content 0.1,0.5,2.0,5.0 g·L-1were (4.8±0.3),(39.4±8.0),(86.3±17.4),(184.6±33.0)μg·h-1·cm-2 respectively.With addition of penetration enhancer such as N,N-DMF(5%) DMSO(5%)、azone(5%) +1,2-trimethylene glycol(5%).it was 1.17,1.27,1.30 higher than that of the control group.CONCLUSION Niosomes can effectively overcome the characteristics of volatile cinnamon oil increase the skin accumulation of drug." @default.
- W2392113829 created "2016-06-24" @default.
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- W2392113829 date "2009-01-01" @default.
- W2392113829 modified "2023-09-26" @default.
- W2392113829 title "Percutaneous permeability of cinnamon volatile oil niosomes" @default.
- W2392113829 hasPublicationYear "2009" @default.
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