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- W2392116573 abstract "A previous phase Ⅲ clinical study showed that the therapeutic effect was clear when the patients with periodontitis were given a single dose of 1.0g tinidazole (TNZ) per day (doubled on the first day) with a total dosage of 4.0g in three days. But ,the adverse reactions in the gastrointestinal and nerve systems also occurred frequently. In the present randomized controlled clinical trial, TNZ dose was changed into 0.5g twice daily for 4 days, the total dose was 4.0 g. 36 patients with periodontitis were treated by TNZ as the test group(TNZ2),and 39 patients treated by metronidazole as control group(MNZ).The 38 patients treated by tinidazole in the phase Ⅲ clinical study as another control group(TNZ1).The clinical effects and the incidence of the adverse reactions were evaluated. The results showed that the clinical parameters(BI,PD,suppuration,S%) in the three groups after taking the drug were remarkebly decreased (P0.001).The effective rates in TNZ2 group (84.4%) and MNZ group (84.6%) were significantly greater than that in TNZ1 group (37.5%)(P0.001).The incidence of adverse reactions had a decreasing tendency by degree for TNZ1 group (52.9%),TNZ2 group (32.4%) and MNZ group (18.4%). At one week after taking drug, S% in TNZ group (87.5%) and MNZ groups (92.9%) showed rebound (P0.01). The results suggest that 1.0 g daily administration of TNZ in periodontitis treatment be changed to 0.5 g twice daily, and it should be used as an adjunctive therapy to mechanical removal of calculus for periodontitis." @default.
- W2392116573 created "2016-06-24" @default.
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- W2392116573 date "1999-01-01" @default.
- W2392116573 modified "2023-09-25" @default.
- W2392116573 title "A STUDY OF TINIDAZOLE ADMINISTRATION IN THE TREATMENT OF PERIODONTITIS" @default.
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