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- W2392121746 abstract "Objective To study the expression of apoptosis inhibited gene survivin and its relationship with the expressions of bcl-2 and bax in meningiomas. Methods Expressions of survivin, bcl-2 and bax proteins were detected by immunohistochemical method (S-P) in 60 samples of meningiomas respectively. The correlation between them was analyzed in combination with clinical pathological data. Results The expression rate of survivin protein was 32.0% in gradeⅠ, 60.0%, in grade Ⅱ, and 86.7% in gradeⅢ, with significant differences among the 3 groups (P0.05). The positive ratio was closely correlated with aggressive behavior (P0.05) and peritumoral edema (P0.05) respectively. Expressions of bcl-2 and bax proteins was positively and negatively correlated with the expression of survivin protein respectively. Conclusion The expression of survivin in meningiomas is closely correlated with its malignancy. Survivin may play an important role in the pathogenesis of malignant meningiomas. Bcl-2 may play a synergic role while bax an antagonistic role to survivin gene in the formation and progression of meningiomas." @default.
- W2392121746 created "2016-06-24" @default.
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- W2392121746 date "2007-01-01" @default.
- W2392121746 modified "2023-09-25" @default.
- W2392121746 title "Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas" @default.
- W2392121746 hasPublicationYear "2007" @default.
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