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- W2392128217 abstract "The results indicated that hrg-1 gene expression increased significantly during VSMC redifferentiation, and reached the peak after VSMCs being induced for 24 hours by serum deprivation and atRA, an was then maintained at a higher level. The changes of HRG-1 mRNA and protein were similar to those of cellular contractile proteins SM #alpha#-actin and SM22#alpha#. It was demonstrated that anti-HRG-1 antibody could be co-precipitated with SM #alpha#-actin, and these two proteins were co-localized in one cell, as shown by co-immunofluorescence staining with HRG-1 and SM #alpha#-actin. Migration ability of VSMCs was dramatically suppressed after being transfected with HRG-1 expression plasmid. It was suggested that HRG-1 was associated with SM #alpha#-actin in cytoplasm, and its expression was related with VSMC differentiation, and HRG-1 participated in construction of cytoskeleton and regulated contraction and migration of VSMCs." @default.
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- W2392128217 date "2004-01-01" @default.
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- W2392128217 title "Expression and function of hypertension related gene hrg--1 during redifferentiation of vascular smooth muscle cells" @default.
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