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- W2392129588 abstract "In this work,we investigated the feasibility of automated synthesis of(S-[11C]-methyl)-D-cysteine(11C-D-MCYS) as positron emission tomography tracer for tumor imaging.11CH3I was prepared by substitution reaction of HI with 11CH3OH,which was obtained from the reaction of LiAlH4 with 11CO2.11C-D-MCYS was produced by 11C-methylation of the precursor D-cysteine with 11CH3I and purification on commercial Sep Pak C18 cartridges.The uncorrected radiochemical yield of 11C-D-MCYS from 11CH3I was over(51±4)%,the radiochemical purity of 11C-D-MCYS was more than 99%,and the total synthesis time was about 12 min.PET imaging studies showed that 11C-D-MCYS had high uptake in the S180 sarcoma-bearing tissues,but low uptake in inflammatory tissues.It seems that 11C-D-MCYS is a potential PET tracer for tumor imaging." @default.
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- W2392129588 date "2012-01-01" @default.
- W2392129588 modified "2023-09-27" @default.
- W2392129588 title "Automated radiosynthesis and preliminary animal experiments of (S-[ 11 C]-methyl)-D-cysteine" @default.
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