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- W2392130180 abstract "To investigate the effect of berberine hydrochloride (BBR) on the proliferation, apoptosis, TNF-α, IL-2 and IFN-γ secretion of splenocytes in mice.The splenocytes isolated from the spleen of mice in a sterile environment were pretreated with BBR at the concentrations of 1, 2, 4 μg/mL for 60 min. Thereafter, the cells were stimulated with polyclonal activators ConA and cultured for 24, 48, 72 h, respectively. MTT assay was used to detect the proliferation of cells; flow cytometry was performed to detect the splenocyte apoptosis according to the fluorescence intensity of the splenocytes stained with PI and annexin V-FITC; the concentrations of TNF-α, IL-2 and IFN-γ in the culture supernate was quantificationally analyzed by the ELISA.Compared with the control group, BBR within the concentration range above significantly inhibited the splenocyte proliferation, TNF-α, IL-2 and IFN-γ secretion of the splenocytes activated by ConA in a dose- and time-dependent manner (P<0.05), but didn't significantly cause the apoptosis of splenocytes (P>0.05).BBR can have immunosuppressive influence on the splenocytes in mice and may act as a potential immunosuppressive drug." @default.
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- W2392130180 date "2013-08-01" @default.
- W2392130180 modified "2023-10-16" @default.
- W2392130180 title "[Effect of berberine hydrochloride on the proliferation, apoptosis and cytokine secretion of splenocytes in mice]." @default.
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