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- W2392133060 abstract "Objective To evaluate the effects of resuscitation with hypertonic saline solution(HSS) on the splenic T lymhocytes in rats with hemorrhagic shock. Methods Controlled hemorrhagic shock was induced by blood withdrawal (MAP, 40 mm Hg) and maintained for 60 min. Animals were randomly divided into 3 groups. Group 1(n=10) was treated with 30 ml/kg normal saline(NS), group 2 ( n=10) with 4 ml/kg HSS and SB203580 (1 mg/kg,ip), and group 3 (n=10) with 4 ml/kg HSS. The rats were killed 24 h after resuscitation.Spleen T lymphocytes were separated,the expression of p38MAPK protein in the lymphocytes was determined by immunol fluorence,and MTT and ELISA were used to determine the IL-2 of T lymhocytes and the ability of splenic lymhocytes proliferation. Results The expression of p38MAPK protein in the spleen lymphocytes was increased significantly in group 3 than that in group 1 and group 2. The productive content of IL-2 in group 3 was significantly higher than that in group 1 and group 2. The T lymhocytes proliferation rate in group 3 was significantly higher than that in the other two groups. Conclusion HSS may improve the function of splenic T lymhocytes in hemorrhagic shock rats through the p38MAPK pathway." @default.
- W2392133060 created "2016-06-24" @default.
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- W2392133060 date "2007-01-01" @default.
- W2392133060 modified "2023-09-24" @default.
- W2392133060 title "Hypertonic saline improves the function of splenic T lymhocytes in rats with hemorrhagic shock" @default.
- W2392133060 hasPublicationYear "2007" @default.
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