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- W2392133663 abstract "Objective:To explore the expression of germ cell nuclear factor(GCNF) in cervical cancer and its role in oncogenesis and development of cervical cancer.Methods:The expressions of GCNF protein and GCNF mRNA were detected by immunohistochemical Envision method and RT-PCR technique in normal cervical tissue,cervical intraepithelial neoplasia(CIN) tissue(CINⅠ,CINⅡ,CINⅢ),and cervical cancer tissue.Results:The expression of GCNF protein in normal cervical tissue,CIN and cervical cancer were 90.0%(18/20),78.3%(18/23),45.0%(9/20),33.3%(9/27),and 3.4%(4/29),respectively,there was statistically significant difference(P0.05).The results of RT-PCR showed the expression of GCNF mRNA was consistent with GCNF protein,the expression of GCNF mRNA in cervical cancer was statistically significantly lower than that in normal cervical tissue.Conclusion:Preliminary view is that the down-regulation or deletion of expressions of GCNF protein and mRNA may be an early signal of cervical cancer.It may provide research direction for targeted therapy of cervical cancer." @default.
- W2392133663 created "2016-06-24" @default.
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- W2392133663 date "2013-01-01" @default.
- W2392133663 modified "2023-09-24" @default.
- W2392133663 title "Expression of germ cell nuclear factor in cervical cancer" @default.
- W2392133663 hasPublicationYear "2013" @default.
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