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- W2392142937 abstract "Objective To investigate the repair effects of bone marrow mesenchymal stem cells(BMSCs) on adriamycin-induced nephritic rats and effects on FAK. Methods The rats models were induced by adriamycin to cause nephritic syndrome. Then, the rats were divided into four groups. The first group was the model without any treatment. The second group were treated with BMSCs. The third group were treated with prednisone. And the forth group were treated with BMSCs and prednisone. The quantitation of proteinuria was tested respectively. Histology of kidney was tested by transmission electron microscope. The expression levels of Nephrin, podocin and Desmin mRNA were tested by RT-PCR. The Nephrin protein levels were tested by immunohistochemistry. The expression level of FAK and phosphorylated FAK-Tyr397 were detected by western blot. Results(1) Compared with normal group, rats in model group developed massive Proteinuria with foot process fusion, while in BMSCs group were significantly ameliorated.(2)Nephrin mRNA expression in model group were lower than normal after adriamycin injection(P0.05), while Desmin and FAK mRNA expression in model group were higher than normal group(P0.05); Nephrin mRNA expression in treatment groups were lower than model group 5 weeks after adriamycin injection(P0.05), while Desmin and FAK mRNA expression in treatment groups were lower than model group(P0.05).(3)Nephrin protein expression in model group and the treatment groups were lower than normal group(P0.05); Nephrin expression in treatment groups were higher than model group three weeks after adriamycin injection(P0.05).(4)FAK total protein and phosphorylated proteins in model group higherthan normal group(P0.01). The protein level of treatment groups lower than model group(P0.05). Conclusion Prednisone and BMSCs play a protective effect in ardriamycin-induced nephrotic rats via the inhibition of FAK and by altering the expression and distribution of Nephrin and moderating the expression of Desmin. BMSCs play a protective effect in ardriamycin- induced nephrotic rats." @default.
- W2392142937 created "2016-06-24" @default.
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- W2392142937 date "2013-01-01" @default.
- W2392142937 modified "2023-09-24" @default.
- W2392142937 title "Effects of bone marrow mesenchymal stem cells on the kidney of adriamycin-induced nephritic rats" @default.
- W2392142937 hasPublicationYear "2013" @default.
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