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- W2392146483 abstract "Objective To study the p53 signal pathway in keratinocytes damaged by ultraviolet B (UVB) irradiation. Methods Cultured normal human epidermal keratinocytes isolated from the foreskins of healthy children were irradiated with UVB in a dose of 20, 60 and 120 mJ/cm2, respectively. The mRNA and protein expression of p53 and its downstream molecules p21, mouse double minute 2 (MDM2), Bax, and growth arrest and DNA damage induced gene 45 (GADD45) was detected by reverse transcription -PCR and Western blotting at 0, 2, 24, and 48 h after the irradiation. Results The mRNA and protein expression of p53 increased significantly at 2 h after UVB irradiation, and the increase continued until 48 h after the irradiation. None of the p53 effector genes (MDM2, p21, GADD45 and Bax) was transcriptionally induced significantly (P 0.05) after irradiation with low dose of UVB. When the dose of UVB reached 60 mJ/cm2, the mRNA and protein expression of both p21 and Bax increased significantly (both P 0.05) in a time-dependant manner, while those of MDM2 increased only transiently at 2 hrs after the irradiation. Conclusions UVB can trigger the activation of p53 signal pathway in keratinocytes. The expression of p53 downstream molecules is increased by UVB irradiation in a dose-and time-dependent manner in keratinocytes." @default.
- W2392146483 created "2016-06-24" @default.
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- W2392146483 date "2006-01-01" @default.
- W2392146483 modified "2023-09-23" @default.
- W2392146483 title "Study on the p53 signal pathway in keratinocytes damaged by ultraviolet B irradiation" @default.
- W2392146483 hasPublicationYear "2006" @default.
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