Matches in SemOpenAlex for { <https://semopenalex.org/work/W2392147918> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2392147918 abstract "AIM To investigate the inhibitory effect of on myocardial hypertrophy induced by isoproterenol via TLR4 / NF-κB inflammation signaling pathway. METHODS Sixty SD rats were randomly assigned to the following six groups( 10 rats for each group) : the control,isoproterenol group,isoproterenol plus astragalus polysaccharide( low,middle and high dose),and isoproterenol plus propranolol. Administered groups were injected intraperitoneally for three weeks,and isoproterenol was injected intraperitoneally for two weeks in the next day of each administration. After all administrations were completed,heart mass index( HMI) and left ventricular mass index( LVMI) of rats in each group were calculated,and pathological section was performed by HE staining. The mRNA expression levels of ANP and TLR4 were measured by RT-PCR and the expression of TLR4,p65,and IκBα in the tissue were measured by Western blot. The expression of TNF-α and IL-6 was measured by ELISA. RESULTS Compared to the control group,isoproterenol group showed the increase of HMI and LVMI,mRNA expression of ANP and TLR4 and the protein expression of TLR4,p65 and TNF-α,IL-6. Whereas the expression of IκBα decreased( P 0. 01). Compared to isoproterenol group,400,800 mg /( kg·d) polysaccharide from Astragali Radix and 40 mg /( kg·d) propranolol decreased HMI and LVMI,and could significantly down-regulate the overexpression of ANP mRNA,TLR4 mRNA,TLR4,p65 and TNF-α,IL-6,and increased the expression of IκBα( P 0. 01). polysaccharide from Astragali Radix 200 mg /( kg·d) decreased ANP mRNA,TLR4 mRNA,TLR4,p65 and TNF-α expression( P 0. 05,P 0. 01),and increased the expression of IκBα( P 0. 05). CONCLUSIONS Polysaccharide from Astragali Radix has a protective effect on isoproterenol-induced cardiac hypertrophy, which is partially via inhibiting the TLR4 / NF-κB signaling pathway." @default.
- W2392147918 created "2016-06-24" @default.
- W2392147918 creator A5056818094 @default.
- W2392147918 date "2014-01-01" @default.
- W2392147918 modified "2023-09-24" @default.
- W2392147918 title "Effect of polysaccharide from Astragali Radix on cardiac hypertrophy induced by isoproterenol via TLR4 /NF-kB signaling pathway in rats" @default.
- W2392147918 hasPublicationYear "2014" @default.
- W2392147918 type Work @default.
- W2392147918 sameAs 2392147918 @default.
- W2392147918 citedByCount "0" @default.
- W2392147918 crossrefType "journal-article" @default.
- W2392147918 hasAuthorship W2392147918A5056818094 @default.
- W2392147918 hasConcept C104317684 @default.
- W2392147918 hasConcept C105580179 @default.
- W2392147918 hasConcept C126322002 @default.
- W2392147918 hasConcept C134018914 @default.
- W2392147918 hasConcept C167414201 @default.
- W2392147918 hasConcept C170493617 @default.
- W2392147918 hasConcept C185592680 @default.
- W2392147918 hasConcept C2776070231 @default.
- W2392147918 hasConcept C2776415932 @default.
- W2392147918 hasConcept C2778151854 @default.
- W2392147918 hasConcept C55493867 @default.
- W2392147918 hasConcept C62478195 @default.
- W2392147918 hasConcept C71924100 @default.
- W2392147918 hasConceptScore W2392147918C104317684 @default.
- W2392147918 hasConceptScore W2392147918C105580179 @default.
- W2392147918 hasConceptScore W2392147918C126322002 @default.
- W2392147918 hasConceptScore W2392147918C134018914 @default.
- W2392147918 hasConceptScore W2392147918C167414201 @default.
- W2392147918 hasConceptScore W2392147918C170493617 @default.
- W2392147918 hasConceptScore W2392147918C185592680 @default.
- W2392147918 hasConceptScore W2392147918C2776070231 @default.
- W2392147918 hasConceptScore W2392147918C2776415932 @default.
- W2392147918 hasConceptScore W2392147918C2778151854 @default.
- W2392147918 hasConceptScore W2392147918C55493867 @default.
- W2392147918 hasConceptScore W2392147918C62478195 @default.
- W2392147918 hasConceptScore W2392147918C71924100 @default.
- W2392147918 hasLocation W23921479181 @default.
- W2392147918 hasOpenAccess W2392147918 @default.
- W2392147918 hasPrimaryLocation W23921479181 @default.
- W2392147918 hasRelatedWork W1989950165 @default.
- W2392147918 hasRelatedWork W2082533107 @default.
- W2392147918 hasRelatedWork W2415797272 @default.
- W2392147918 hasRelatedWork W2590378081 @default.
- W2392147918 hasRelatedWork W2810275203 @default.
- W2392147918 hasRelatedWork W2891168323 @default.
- W2392147918 hasRelatedWork W2981289522 @default.
- W2392147918 hasRelatedWork W2988451950 @default.
- W2392147918 hasRelatedWork W3003454357 @default.
- W2392147918 hasRelatedWork W3012608857 @default.
- W2392147918 hasRelatedWork W3029189729 @default.
- W2392147918 hasRelatedWork W3030504614 @default.
- W2392147918 hasRelatedWork W3030926582 @default.
- W2392147918 hasRelatedWork W3032591695 @default.
- W2392147918 hasRelatedWork W3045936493 @default.
- W2392147918 hasRelatedWork W3088419516 @default.
- W2392147918 hasRelatedWork W3127611901 @default.
- W2392147918 hasRelatedWork W3168354197 @default.
- W2392147918 hasRelatedWork W2612744537 @default.
- W2392147918 hasRelatedWork W3031200190 @default.
- W2392147918 isParatext "false" @default.
- W2392147918 isRetracted "false" @default.
- W2392147918 magId "2392147918" @default.
- W2392147918 workType "article" @default.