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- W2392159580 abstract "Human cervix cancer HeLa cell was taken as an object of study. Immunoblot (Western blot), flow cytometry(FCM)and indirect immunofluorescence-flow cytometry(IIF FCM)techniques were used to analyze the effects of anti-tumor drug harringtonine (HT) on the proliferation and apoptosis of HeLa cell, the expression level of CenpB was detected and make further exploration of the relationship between CenpB gene and cell proliferation and the effect of HT. The results are as follows: The G1 phase was shortery and S phase was extended with the prolongtion of treatment time by 0.2 μg/mL HT in HeLa cell, the transmission from G2 phase to G1 phase is postponed slowly;Apoptosis rate shows an increasing trend;Compared to the untreated control cells, the effect of 0.2 μg/mL HT contributes to the decrease of the expression of CenpB protein, however not a simple function relationship is given by the data: At or before the 12 h time point, there is a deviation from the total tendencies of the trend. This may be the effect of the feedback regulation of drug induced by cell cycle checkpoints, and the gene expression of CenpB, an important centromere constitutive protein, may be related to it distinctly." @default.
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- W2392159580 date "2005-01-01" @default.
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- W2392159580 title "Effects of anti--tumor drug harringtonine on the proliferation of HeLa cell and its relationship with {sl CenpB} gene" @default.
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