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- W2392160939 abstract "AI M:Tostudythe toxic effects of HUonreproductive systemin male rats .METHOD:Byintrap-eritoneal injection, HUwere administratedto male Wistarrats at different doses of (100 ,200 ,and 400 mg·kg-1)once a dayfor 10 days ,andthe rats were randomlysacri-ficed onthe 9th and twentieth-third days after withdrawalof HU,respectively.RESULTS:Inactive spermin 200and 400 mg·kg-1group was higher thanthat inthe con-trol group on the 9th after withdrawal . On the twentieth-third after withdrawal ,the testis/body ratios ,three treat-ment groups were decreased significantly than that in thecontrol group (P0 .05 ,orP0 .01) ,the epididy-mides/ body ratios was decreased significantly in 400mg·kg-1group, and inactive sperm remains had de-creased significantly (P0 .01) ,200 ,400 mg·kg-1groups of the number of spermhad decreased significantlythan that in the control group (P0 .01) . In thegroups treated,the rates of spermdeformity were signifi-cantly higher thanthat of the control ,and the higher theexpose concentration of HU,the higher the rate of spermdeformity on the 9th and the twentieth-third (P0 .01) .CONCLUSION: HUcanresult inthe obviouslyadverse effects onthe reproductive systemof male rats ,itsaimorgans may be testis and epididymis ,and affect thecourse of spermatogenesis . After withdrawal ,these dam-ages are hard to recover and still development within acertaintime ." @default.
- W2392160939 created "2016-06-24" @default.
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- W2392160939 date "2005-01-01" @default.
- W2392160939 modified "2023-09-23" @default.
- W2392160939 title "Study on reproductive toxicity of hydroxyurea in male rat" @default.
- W2392160939 hasPublicationYear "2005" @default.
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