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- W2392164443 abstract "[Objective] To investigate the acute toxic effects of PM2.5 and nickel sulfate(NiSO4),a toxic metal components in PM2.5,on blood coagulation in Wistar rats.[Methods] Twenty-eight male Wistar rats were divided into four groups for each experiment.In PM2.5 experiment,PM2.5 was administered by intratracheal instillation at the single dose of 0mg/kg,7.5mg/kg,15mg/kg and 30mg/kg,respectively.In NiSO4 experiment,NiSO4 was administered under the same manner at the dose of 0μg Ni/kg,7.5μg Ni/kg,75μg Ni/kg and 750μg Ni/kg,respectively.PM2.5 at the dose of 15mg/kg contains 7.5μg Ni.The rats were sacrificed after 24h of instillation,blood samples were collected and indices of blood coagulation(plasma prothrombin time(PT),plasma-activated partial thromboplastin time (APTT),fibrinogen (Fib),and tissue factor(TF))were measured.[Results] PT levels in the plasma decreased significantly in PM2.5-treated rats compared with the control group,while there were no changes with APTT.Plasma fibrinogen increased significantly at 15mg/kg and 30mg/kg PM2.5 groups.The TF concentrations in plasma increased significantly at 7.5mg/kg bw PM2.5 group,while the high-dosage groups (15,30mg/kg bw groups) only showed slight increase.The PT and APTT showed no changes in NiSO4-treated rats.Plasma fibrinogen levels increased significantly at 750μg Ni/kg NiSO4-treated rats.The TF concentrations in plasma increased significantly at 75μg Ni/kg and 750μg Ni/kg dosage groups(P 0.05),there was a slight increase in low dosage (7.5μg Ni/kg) group.[Conclusion] PM2.5 induced changes in blood coagulation function in rats.The administration of NiSO4 to rats induced similar pathological changes caused by PM2.5.This study suggested that NiSO4 may partially contribute to the blood coagulative effects of PM2.5 on rats." @default.
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- W2392164443 date "2010-01-01" @default.
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- W2392164443 title "Comparative study on parameters of blood coagulation affected by PM2.5 and nickel sulfate intratracheal instillation in rats." @default.
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