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- W2392165891 abstract "Objective To find out if strict microorganism controlled SPF animals are suitable as models of human being living in natural environment.Method 40 SPF Wistar rats and 200 BALB/c mice were assigned into two groups respectively.Group 1 was housed in barrier system,while group 2 was kept in open system.The body weight of rats and mice were measured weekly.After having been kept in the experimental environment for 35 days,14 hematology and 15 serum chemistry parameters were analyzed and 9 organ weights were measured in rats.Anoxic resistance test and swimming test were conducted in mice.Acute toxicity test of 5-fluorouracil and pentobarbital sodium anaesthesia test were also carried out in mice.Results Rats and mice housed in barrier systems grew faster than that in open systems(P0.05).The values of RBC,WBC,PCT,PLT,GOT,GGT,GPT,CK,TB of rats kept in barrier system were lower than that in open system(P0.05),while the values of CHO,LDL-C,HDL-C of rats in barrier system were higher than that in open system(P0.05).There was no significant difference of relative organ weights between the two groups.No significant difference was found in anoxic resistance test and swimming test between the mice in the two groups,but the variation of enduring time of mice kept in barrier systems was less comparing with that in the open system.The reaction to pentobarbital sodium anesthesia and 5-fluorouracil toxicity were similar between the two mouse groups when dosed at the same level,but the shorter duration of anesthesia,less LD_(50) and narrower 95% reliability range were showed in the mice in barrier system.Conclusion There were some differences of biological characteristics of animals kept in barrier system and open system,but the ability to resist stress and the reaction to pentobarbital sodium and 5-fluorouracil were similar.Animals kept in barrier system appeared more 'healthy',and were more sensitive and more reliable in experiments.It revealed that the SPF animals with strict microorganism control could be the models of human being living in natural environment." @default.
- W2392165891 created "2016-06-24" @default.
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- W2392165891 date "2008-01-01" @default.
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- W2392165891 title "Effect of Different Grade Environment on Mice and Rats" @default.
- W2392165891 hasPublicationYear "2008" @default.
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