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- W2392175088 abstract "Objective To prepare antiviral drugs lopinavir. Methods Lopinavir was synthesized from( 2S,3S,5S)-5-tert-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane reaction with 2,6-Dimethylphenoxyacetic acid by condensation deprotection,which was subjected to condensation with( 2S)-( 1-Tetrahydropyramid-2-one)-3-methylbutanoic acid. Results The target product was synthesized via three-step procedure starting from BDC in a total yield of 50. 7% and its structure was confirmed by1H-NMR,ESI-MS. Conclusions The method of preparation is much easier to perform,with simple work-up and fewer by-products. It is suitable for industrial production." @default.
- W2392175088 created "2016-06-24" @default.
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- W2392175088 date "2013-01-01" @default.
- W2392175088 modified "2023-09-22" @default.
- W2392175088 title "Synthesis of lopinavir" @default.
- W2392175088 hasPublicationYear "2013" @default.
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