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- W2392181542 abstract "Objective To evaluate the efficacy and safety of amisulpride in the treatment of adolescents with schizophrenia.Methods 68 adolescent patients with schizophrenia were randomized into study group( 34 cases) treated with amisulpride and control group( 34 cases) treated with risperidone for 8 weeks. All patients were assessed with Positive and Negative Syndrome Scale( PANSS) and Calgary Depression Scale for Schizophrenia( CDSS) at baseline and at the end of the treatment to evaluate the efficacy. Treatment Emergent Symptom Scale( TESS) was used to evaluate the side effects. Results There was no significant difference in response rate between study group and control group( 87. 5% vs. 78. 8%,χ2= 0. 858,P 0. 05).Reduction of factor score of negative symptoms in PANSS and reduction of total score of CDSS in study group were significantly higher than those in study group( P 0. 05). The frequencies of akathisia,cardiovascular side effects,weight gain,hyperprolactinemia in study group were significantly lower than those in control group( P 0. 05). Conclusion The efficacy of amisulpride is equivalent to risperidone for treating adolescents with schizophrenia. But amisulpride has more advantage than risperidone in improving negative and depressive symptoms." @default.
- W2392181542 created "2016-06-24" @default.
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- W2392181542 date "2014-01-01" @default.
- W2392181542 modified "2023-09-27" @default.
- W2392181542 title "Control study of efficacy of amisulpride vs. risperidone in the treatment of adolescents with schizophrenia" @default.
- W2392181542 hasPublicationYear "2014" @default.
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