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- W2392181618 abstract "Objective: To establish a method for the determination of Biapenem in human plasma by HPLC.Methods: Agilent ZORBAX Bonus-RP(4.6 mm×250 mm,5 μm) was used as the analytical column;mobile phase was composed of methanol-0.03% acetic acid solution(gradient elution);the flow rate was 1.00 ml/min;the UV detection was carried out at 300 nm.The plasma samples were performed by protein precipitation with ZnSO4 using 5-hydroxyindole acetic acid as internal standard sample.Results: The assay was linear over the concentration range of 0.2-50.0 μg/ml for Biapenem in human plasma.The limit of quantitation for biapenem was 0.2 μg/ml.The retention time of Biapenem and internal standard sample in plasma was 3.9 min and 9.7 min,respectively.The recovery rate at concentrations of 0.5,5.0,40.0 μg/ml were 101.8%,100.8%,100.4%,respectively.The method was accurate with all intra-day and inter-day mean concentrations within 15% of nominal values.Furthermore,the stability results showed that Biapenem was stable during sample processing(RSD15%).Conclusion: This method is high sensitive,operation simple,fast and repeatable,which is suitable for determination of Biapenem in human plasma." @default.
- W2392181618 created "2016-06-24" @default.
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- W2392181618 date "2011-01-01" @default.
- W2392181618 modified "2023-09-23" @default.
- W2392181618 title "Studies on the concentration and bioequivalence of the Biapenem in human plasma by HPLC" @default.
- W2392181618 hasPublicationYear "2011" @default.
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