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- W2392187079 abstract "Objective:To discuss the influence of QiShenYiQi Gutta Pills(QGP)on expression of vascular endothelial growth factor(VEGF),pigment epithelium derived factor(PEDF)and mRNA expression of VEGF and PEDF in rats with diabetic retinopathy.Methods:The diabetic rat model was established by one-time injection of streptozotozin(STZ,65mg/kg).All SD rats(n=82)were randomly divided into the normal group,model group, control group and QGP group.After 10 months,the expression of VEGF and PEDF was detected by immunohistochemistry method,VEGFmRNA and PEDFmRNA were examined by reverse transcription-polymerase chain reaction(RT-PCR).Results:The expression of VEGF and VEGFmRNA in model group was higher than that in the normal group(P0.01).The expression of PEDF and PEDFmRNA in model group was lower than the normal group(P0.01).The expression of VEGF and VEGFmRNA in QGP group was lower than that in the model group(P0.01).The expression of PEDF and PEDFmRNA in QGP group was higher than the model group(P 0.01).Conclusion:QGP can delay the development of diabetic retinopathy in rats through decreasing the expression of retinal VEGF and VEGFmRNA,and increasing the expression of retinal PEDF and PEDFmRNA." @default.
- W2392187079 created "2016-06-24" @default.
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- W2392187079 date "2013-01-01" @default.
- W2392187079 modified "2023-09-23" @default.
- W2392187079 title "Influence of Qishenyiqi Gutta Pills on expression of vascular endothelial growth factor and pigment epithelium derived factor in retina of diabetic rats" @default.
- W2392187079 hasPublicationYear "2013" @default.
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