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- W2392187855 abstract "Objective: To observe the distribution and expression of integrin β1 during mandibular distraction osteogenesis.To investigate the function of integrin β1 in the transduction of mechanical stimuli to sensory cell during mandibular osteodistraction. Methods: Bilateral mandibular osteotomies were performed in 12 rabbits. The mandibles were lengthened 6mm using a custom-made distractor with a rate of 1mm/d. 3 rabbits were killed respectively at the end of delay period and 0、7 and 14 days, distraction. The distracted calluses from all animals were harvested and processed for immunohistochemistry staining for integrin β1. Semi-quantitative analysis was used to evaluate immunohistochemical staining. Results: Immunohistochemical staining of integrin β1 was localized in the mesenchymal cells at distraction gap and osteoblast lining on the surface of trabecular columns. The majority of mesenchymal cells and osteoblastic cells failed to immmunodetectable reactions at the end of latency. After 0 day's distraction, a marked gradient increase of expression was readily visible in the regenerated tissue. After the 7 and 14 days distraction, the intensity of its expression was significantly weaker than that of 0 day. Conclusion: The results suggest that integrin β1 may play an important role in the transduction of mechanical stimuli to sensory cell and interpret intracellular proliferation and differentiation messages during distraction osteogenesis." @default.
- W2392187855 created "2016-06-24" @default.
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- W2392187855 date "2005-01-01" @default.
- W2392187855 modified "2023-09-23" @default.
- W2392187855 title "The Function of Integrin β1 in the Transduction of Mechanical Stimuli to Sensory Cell during Mandibular Osteodistraction." @default.
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