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- W2392196464 abstract "Objective To compare liver biochemical changes and morphological characteristics of CCl4-induced chronic liver injury between SD and Wistar rats models.Methods 25 SD rats(SD group) and 25 Wistar rats(Wistar group) were respectively given 50% CCl4(0.3 mL/100 g,diluted with peanut oil) by subcutaneous injection,twice a week for eight weeks.The samples were collected after eight weeks.The content of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),albumin(ALB) in serum were detected by automatic biochemical analyzer;hyaluronic acid(HA),laminin(LN),procollagen Ⅲ(PⅢ),and IV collagen(IV-C) were detected in serum by radioimmunoassay,Liver tissue samples were detected with the conventional HE and reticular fiber staining.Results The activity of ALT,AST and the content of TBIL,ALB and HA,LN and PⅢ in serum in Wistar group were higher than those in SD group(P0.05 or P0.01);Hepatic steatosis in Wistar group significantly increased than SD group,but the extent of liver fibrosis in SD group was more conspicuous than Wistar group.Conclusion CCl4-induced liver fibrosis and hepatic steatosis are closely related with animal species." @default.
- W2392196464 created "2016-06-24" @default.
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- W2392196464 date "2009-01-01" @default.
- W2392196464 modified "2023-09-25" @default.
- W2392196464 title "Comparison of Liver Fibrosis in SD,Wistar Rats Induced by CCl_4" @default.
- W2392196464 hasPublicationYear "2009" @default.
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