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- W2392203481 abstract "Objective To explore effects of erythromycin on fast response action potential.Methods Conventional microelectrode technique was employed to record the fast response action potenital of the isolated papillary muscles of guinea pigs.Specific blockers of potassium channels such as chromanol 293B and dofetilide were used to study the effects of erythromycin on the Ikr and Iks.Results Erythromycin could prolong action potential duration and effective refractory period in the fast response action potential of the guinea pigs.The maximum depolarization velocity of 0 phase decreased.Erythromycin prolonged action potential duration on the basis of chromanol 293B,but it didn′t prolong action potential duration after using dofetilide.Conclusion Erythromycin may induce arrhythmia by inhibiting sodium and potassium ion channels,especially Ikr." @default.
- W2392203481 created "2016-06-24" @default.
- W2392203481 creator A5082495546 @default.
- W2392203481 date "2009-01-01" @default.
- W2392203481 modified "2023-09-23" @default.
- W2392203481 title "Cardiac Electrophysiological Effect of Erythromycin" @default.
- W2392203481 hasPublicationYear "2009" @default.
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