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- W2392219647 abstract "Objective To study the change and significance of endothelin-1(ET1) protein expression and GATA DNA binding activity in myocardium of rats with left ventricular hypertrophy induced by pressure overload and investigate the effects of telmisartan on hemodynamic parameters(systolic blood pressure(SBP),diastolic blood pressure(DBP) and mean blood pressure(MBP)),left ventricular mass index(LVMI) and transverse diameter of myocardial cell(DC) as well as ET-1 protein expression and GATA DNA binding activity in myocardium of rats with left ventricular hypertrophy induced by pressure overload.Methods Experimental rats with left ventricular hypertrophy induced by pressure overload were established by partially banding abdominal aortic artery.24 healthy SD rats were randomly divided into three groups: sham-operated group(n=8);operated group(n=8) and telmisartan group(telmisartan 3 mg·kg-1·d-1 per gavage,from 7th day to 4 weeks after operation,n=8).Hemodynamic parameters,LVMI and DC were measured.ET-1 protein expression in myocardium was determined by immunohistochemistry assay.The specific combination of ET-1 with GATA and GATA DNA binding activity were analyzed with electrophoretic mobility shift assays(EMSA).Results Compared with sham-operated group,SBP,DBP,MBP,LVMI,DC,ET-1 protein expression and GATA DNA binding activity were significantly increased(all P0.05);and ET1 protein expression was correlated positively with LVMI and DC(r=0.895,r=0.899,all P0.01) in operated group.Compared with the operated group,SBP,MBP,LVMI,DC, ET-1 protein expression and GATA DNA binding activity were significantly reduced in telmisartan group(all P0.05).Conclusions(1) The upregulation of ET-1 protein expression triggered by increase of GATA DNA binding activity is correlated with left ventricular hypertrophy of rats induced by pressure overload.(2) Telmisartan can prevent left ventricular hypertrophy of rats induced by pressure overload through downregulation ET-1 protein expression by decrease of GATA DNA binding activity." @default.
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- W2392219647 date "2010-01-01" @default.
- W2392219647 modified "2023-09-25" @default.
- W2392219647 title "Effects of telmisartan on endothelin-1 protein expression and GATA DNA binding activity in rats with left ventricular hypertrophy induced by pressure overload" @default.
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