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- W2392221908 abstract "Objective To study the effects of SBA-15 on the activity of human umbilical vein endothelial cells(HUVEC) and expression levels of inflammatory factors C-reactive protein(CRP) and monocyte chemotactic factor 1(MCP-1) mRNA.Methods HUVEC were exposed to the RPMI1640 medium containing a final concentration of 0(solvent control),25,50,100 and 200 μg/ml of SBA-15 and 100 μg/ml micron silica to be cultured for 24 h.The inhibition of cell proliferation,lactate dehydrogenase(LDH) activity in the medium supernatant and expression levels of CRP and MCP-1 mRNA were detected.Results Compared with the solvent control group,the inhibition rate,LDH activity in the medium supernatant and expression levels of CRP and MCP-1 mRNA of cells exposed to SBA-15 were significantly increased;and with the increase of the SBA-15 exposure concentration,HUVEC inhibition rate,LDH activity in the medium supernatant and expression levels of CRP and MCP-1 mRNA showed an upward trend.Conclusion SBA-15 has toxic effects on HUVEC." @default.
- W2392221908 created "2016-06-24" @default.
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- W2392221908 date "2013-01-01" @default.
- W2392221908 modified "2023-09-26" @default.
- W2392221908 title "Effects of SBA-15 on apoptosis of human umbilical vein endothelial cells" @default.
- W2392221908 hasPublicationYear "2013" @default.
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