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- W2392227279 abstract "AIM For comprehensive understanding the action of minocycline on central nervous system. METHODS Cortical neurons were isolated from new born rats, primarily cultured for different days, treated by minocycline and/or N methyl D aspartate(NMDA) at different concentrations for different durations. After treatment, neurons were photographed, and their viability was evaluated by MTT assay. RESULTSMinocycline cultured at 135 μmol·L-1 for 24 h markedly reduced the viability of the neurons at 4, 7, 10 d in vitro (P0.01), but had no effect at 13.5 μmol·L-1 or less. Minocycline at 45 and 135 μmol·L-1 for 3 h did not reduce the viability of the neurons at 10 d in vitro, but reduced the viability when treated for 24 h. On the other hand, minocycline at 45 and 135 μmol·L-1 protected the neurons against the damage induced by 50 μmol·L-1 NMDA for 3 h, but had no effect on the damage induced by 15 μmol·L-1 NMDA for 24 h. However, a lower concentration of minocycline (15 μmol·L-1) could protect against the damage induced by 15 μmol·L-1 NMDA for 24 h. CONCLUSION Minocycline possesses both toxic and neuroprotective effects on rat primary cortical neurons. It can damage the neurons under longer exposure at higher concentrations, but protect the neurons from acute damage at higher concentrations and delay the damage at lower concentrations." @default.
- W2392227279 created "2016-06-24" @default.
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- W2392227279 date "2004-01-01" @default.
- W2392227279 modified "2023-09-23" @default.
- W2392227279 title "Neurotoxicity of minocycline and its protective effect on N-methyl-D-aspartate-induced damage in rat cortical neurons" @default.
- W2392227279 hasPublicationYear "2004" @default.
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