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- W2392245786 abstract "Objective:To investigate co-mutagenic effect of Microcystin-LR(MCLR)by the combination with N-nitrosodiethylamine (DEN)in the lacZ transgenic mouse (Muta TMMouse).Methods:LacZ gene was recovered through in vitro packing .Mutant frequencies (MFs)of liver and lung were examined after intraperitoneal treatment with DEN(25 mg/kg)as well as treatment with MCLR(1 mg/kg)and DEN once each week for 4 weeks.Simultaneously,the clastogenicity of each treatment group was evaluated by the peripheral blood micronucleus assay.Results:The mean frequency of micronucleated reticulocytes (MNRETs)did not increase by the treatment with DEN or co-treatment with MCLR and DEN.There were not significant difference of MFs between DEN-treated organs and co-treated ones by DEN and MCLR.Conclusion:MCLR has no synergistic effect induced by carcinogen DEN in LacZ transgenic mouse." @default.
- W2392245786 created "2016-06-24" @default.
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- W2392245786 date "2005-01-01" @default.
- W2392245786 modified "2023-09-24" @default.
- W2392245786 title "CO-MUTAGENIC EFFECT INDUCED BY MICROCYSTIN-LR AND N-NITROSODIETHYLAMINE IN THE LACZ TRANSGENIC MOUSE" @default.
- W2392245786 hasPublicationYear "2005" @default.
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