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- W2392246766 abstract "Objective To investigate the correlation of the polymorphisms of the IL-1β promoter region-511C/T and tumor necrosis factor-α(TNF-α)-308G/A gene with the susceptibility of non-cardiac gastric cancer of Shaanxi Chinese population.Methods The polymorphisms in the IL-1β promoter region and TNF-α were determined by PCR-RFLP in a Han nationality of Shaanxi Chinese population.Totally 106 cases of non-cardiac gastric cancer and 108 cases of non-ulcer dyspepsia as controls were subjected to IL-1β and TNF-α gene analysis.Results IL-1β genotype frequencies of CC,CT and TT were 12.3%,54.7% and 33% in gastric cancer group;16.7%,50.9%,32.4% in control group respectively.Allele frequencies of C and T were 39.6%,60.4% in gastric cancer group;42.1% and 57.9% in control group respectively.TNF-α-308 genotype frequencies of GG,GA and AA were 90.6%,1.9% and 7.5% in gastric cancer group;84.3%,12.9%,2.8% in control group respectively.Allele frequencies of G and A were 91.5% and 8.5% in gastric cancer group;85.6% and 14.4% in control group respectively.There were no significant differences in the allele frequency and genotype of IL-1β-511C/T and TNF-α-308(P0.05).Conclusion Neither the-511C/T polymorphism in the IL-1β promoter region nor TNF-α-308 gene polymorphism was associated with susceptibility of non-cardiac gastric cancer in a Han nationality of Shaanxi Chinese population." @default.
- W2392246766 created "2016-06-24" @default.
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- W2392246766 date "2009-01-01" @default.
- W2392246766 modified "2023-09-23" @default.
- W2392246766 title "Correlation of polymorphisms of the IL-1 promoter region and tumor necrosis factor alpha gene with susceptibility of non-cardiac gastric cancer in a Han nationality of Shaanxi Chinese population" @default.
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