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- W2392249918 abstract "Objective:To synthesize 1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone and observe its inhibition effect on ovarian carcinoma cells SKOV3.Methods:1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone was synthesized from emodin,and its structure was identified by IR,1H-NMR and 13C-NMR spectra.MTT assay was used to determine the IC50s of 1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone and carboplatin against SKOV3 and HUVEC cells in the single cell system or the condition medium of co-culture cell system,respectively.Results:The structure of 1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone was confirmed by IR,1H-NMR and 13C-NMR.In the single cell system,the IC50s of the synthetic product and carboplatin were 111.72 and 177.63μmol·L-1 against SKOV3 cells,and 198.11 and 131.53μmol·L-1 against HUVEC cells,respectively.In the condition medium of co-culture system,the IC50s of the synthetic product and carboplatin were 104.48 and 180.7μmol·L-1 against SKOV3 cells,and 239.22 and 178.62μmol·L-1 against HUVEC cells,respectively.Conclusion:Compare with carboplatin,1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone shows stronger antiproliferative activity against SKOV3 cells in the condition medium of co-culture system.There is difference in the drug screening result between the single cell system and the condition medium of co-culture cells system." @default.
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- W2392249918 date "2012-01-01" @default.
- W2392249918 modified "2023-09-27" @default.
- W2392249918 title "Synthesis of 1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone and its inhibition effect on ovarian carcinoma cells SKOV3" @default.
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