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- W2392257369 abstract "Objective To evaluate the clinical application of dopamine D_2 receptor (D_2R) 131 I-epidepride SPECT imaging in early stage Parkinson' disease (PD). Methods Ten healthy controls and forty-six untreated patients with early stage PD [Hoehn and Yahr (H-Y) stage Ⅰ 22 cases, H-Y stage Ⅱ 24 cases] were observed with dopamine D_2R 131 I-epidepride SPECT imaging.Striatal specific uptake of 131 I-epidepride was calculated with region of interest analysis according to the ratios of striatum to occipital cortex [(ST-OC)/OC] and of striatum to frontal cortex [(ST-FC)/FC]. Results No obvious side-to-side differences were observed in controls. (ST-OC)/OC and (ST-FC)/FC in the striatum contralateral to the clinical symptom were significantly upgraded compared to ipsilateral side in PD of H-Y stage Ⅰ and H-Y stage Ⅱ. (ST-OC)/OC and (ST-FC)/FC in the striatum significantly rose as the severity increasing and all the increments were significantly higher compared with that in the controls. Conclusion Dopamine D_2R 131 I-epidepride SPECT imaging in human brain will conduce to the diagnosing of early stage PD." @default.
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- W2392257369 date "2003-01-01" @default.
- W2392257369 modified "2023-09-26" @default.
- W2392257369 title "Study on brain dopamine D_2R ~(131)I-epidepride SPECT imaging in patients with early stage Parkinson's disease" @default.
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