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- W2392259083 abstract "Objective:To obsevre the situ focal cortical dysplasia (microgyria) epileptogenicity and the expression of GABA and GABAARα1. Methods: Three groups were performed in the experiment including freeze-lesioned,sham-operated and normal groups. Newborn Wistar rats (24 hr old;n=12) was cooled with liquid nitrogen on the exposed calvaium above the primary parietal cortex (par1) in freeze-lesioned groups. All rats were allowed to survive for 16-18 weeks before HE,Nissl Stain and SABC methods were Performed in the brains. The structure of microgyrus and expression of GABA and GABAARα1 subunit in the animal model were obsrved. Results: All freese-lesioned animals displayed typical cortical malformations consisting of a longitudinal microgyrus. There are chances of GABA and GABAARα1 subunit in cortical dyspiasia,CAland dentate gyru. Only the optical densities of GABA-im-munoreactive neurons and GABAaRα1-immunoreactive neurons located Fr,microgyria,CA1 of hippocampus and dentate gyru of the lesion was significant(P0. 05) between the experimental groups and the two control groups. Conclusion: Decreased expression of GABA and GABAARα1 subunit surrounding microgyrus ,microgyrus,CA1 and dentate gyru could be important mechanism in an intrinsic epileptogenicity of cortical dysplasias." @default.
- W2392259083 created "2016-06-24" @default.
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- W2392259083 date "2006-01-01" @default.
- W2392259083 modified "2023-09-27" @default.
- W2392259083 title "Expression of GABA and GABA_ARα_1 in cortical regions and hippocampal formation to focal cortical dysplasia by freeze-lesioned in rats" @default.
- W2392259083 hasPublicationYear "2006" @default.
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